CTCR maintains a granular genetic database with clinical information to help understand the association of germline mutation profile with disease presentation & prognosis.
Several research projects such as unbiased germline mutational profiling of breast cancer patients conducted at the centre will help understand the nature of inherited breast cancer in the cohort. Hereditary breast cancer, caused by mutations in breast cancer pre-disposing genes, accounts for around 5-10% of total breast cancer cases. However, the burden of hereditary breast cancer in India is not well understood. As per international guidelines, genetic testing and counselling is offered to patients with a strong family history of cancer or early age of onset. Identification of germline mutations influences the patient’s treatment regimen and impacts their immediate family due to its inherited nature. Pre and post-test counseling is thus essential in understanding the importance and role of genetic testing in breast cancer.
